Multimedia

Multimedia
[Southern Arizona VA Healthcare System] [University of Arizona] [Campaign Arizona] [The University of Arizona Foundation ] [Arizona Health Sciences Center]

	Organism C. immitis
	Lung Infection
	Skin Involvement
	Brain Involvement

Clinical Information

	Photos of Clinical Presentations
	Photos of gross tissdue specimens
	Photos of microscopic findings
	Colonial appearance

Interviews

All interviews require RealPlayer. if you don’t have realplayer please click on link below:

Interview with Infectious Disease Specialist
John N. Galgiani, M.D.

Click here to listen to the interview

This recording is an interview with Dr. Galgiani, discussing valley fever symptoms, clinical presentations, treatment, immunity and why early diagnosis is important.

Interview with veterinarian Lisa Shubitz, DVM

Click here to listen to the interview

This recording is an interview with Dr. Shubitz, discussing valley fever symptoms and treatment in dogs and other animals.

Lecture on Coccidioidomycosis by Dr. David A. Stevens, M.D.

Click here to listen to the interview

This video recording is lecture by Dr. Stevens given to medical practitioners at University Medical Center

(University of Arizona, College of Medicine) in Tucson, Arizona.

Histopathology

Microphotographs with Light Imaging of Coccidioidomycosis
Images courtesy of: 1st Institute of Pathology & Experimental Cancer Research,
Semmelweis University of Medical Sciences, Budapest, Hungary

Organism C. immitis

Coccidioidomycosis (spherule)

Coccidioidomycosis (KOH) rupturing mature spherule

Coccidioidomycosis (arthroconidia from colony)

Lung: large spherule on right side of image

Lung (hematoxylin-eosin stain)

Lung (hematoxylin-eosin stain)

Lung (hematoxylin-eosin stain)

Lung (hematoxylin-eosin stain)

Lung spherule (PAS stain)

Lung (Gomori's silver) hyphal elements and spherules

Lung (Gomori's silver)

Lung (Gomori's silver) spherules & endospores

Lung (Gomori's silver) hyphal elements & spherules

Lung (silver methenamine) spherules

Lung, hyphal form, Gomori, spherules

Skin Involvement

Skin & accessories

Skin (Gomori's silver)

Brain Involvement

Brain, large maturing spherules

Meningitis, cerebral membranes

Brain, basilar meningitis, gross dissection

Clinical Information

Photos of Clinical Presentations

Coccidioidomycosis:
Osteomyelitis and subcutaneous involvement of the toe and surrounding tissue
(Bone and tissue disease caused by Coccidioides immitis, the fungus which causes "Valley Fever")

Erythema multiforme (a rash that may accompany infection)

Erythema multiforme, bulbous form

Erythema nodosum (A rash that commonly accompanies early infection)

Subcutaneous abscesses on back

Osteomyelitis with draining sinus

Photos of Gross Tissue Specimens

Lung with coccidioidal cavity
(Photo courtesy of James Byers III, M.D.)

Spleen with multiple foci of infection, demonstrating disseminated disease
(Photo courtesy of James Byers III, M.D.)

Photos of Microscopic Findings

Coccidioidal spherule found in spleen pictured previously: the spherule contains innumerable endospores which mature and are released when the spherule ruptures. The endospores then re-infect and form more spherules.
(Photo courtesy of James Byers III, M.D.)

Coccidioidal spherule found in sputum stained with Papanicolaou's stain. Coccidioidal spherules, if present, may be found when sputum or other respiratory specimens are submitted for detection of lung cancer cells.

Colonial appearance:

Mycelial form of a mature colony of Coccidioides immitis growing on blood agar culture medium. The filamentous hair-like extensions break up into microscopic arthroconidia ("spores") which are easily dispersed by the wind when soil is disturbed.
(photo courtesy of Michael Saubolle, Ph.D.)

Coccidioidal spherule in tissue

Copyright © 1998 Valley Fever Center for Excellence vfever@email.arizona.edu

All rights reserved. Do not redistribute without permission.